Native Proteins and Derivatives
Cayman Chemical 13-methyl Pentadecanoic Acid methyl ester, Purity: ≥98%, CAS: 5487-50-3, 20 mg
A methylated fatty acid methyl ester; has been found in the bioactive fraction of A. malabarica extract, C. variabilis microalgae, and baboon liver
Cayman Chemical 3'-O-Methylguanosine-5'-O-triphosphate (sodium salt), Purity: ≥95%, CAS: 98923-57-0, 2.7 mg
A methylated derivative of GTP; has been used as a chain termination reagent in the preparation of early RNA polymerase II elongation intermediates
Biotium MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1)(2F6), CF568 conjugate, 0.1mg/mL
Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NFB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.
CPC Scientific Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH (trifluoroacetate salt) 25MG
For exerting its anti-inflammatory and immunomodulatory activity, the peptide hormone thymulin, pEAKSQGGSN, requires the presence of Zn(II). Thymulin showed promising results in experimental models of lung diseases as well as potential as an analgesic peptide.ONE-LETTER SEQUENCE: Pyr-AKSQGGSNMOLECULAR FORMULA: C33H54N12O15MOLECULAR WEIGHT:858.86STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [63958-90-7], RESEARCH AREA: ImmunomodulationREFERENCES: J.F.Bach et al., Bull. Inst. Pasteur, 325 (1978); T.L.K.Low and A.L.Goldstein, Springer Semin. Immunopathol., 2, 169 (1979); J.J.E.Haddad et al., Biochem. Biophys. Res. Commun., 274, 500 (2000); S.C.Land and F.Darakshan, Am. J. Physiol. Lung Cell. Mol. Physiol., 286, L473 (2004); M.Dardenne et al., Ann. N. Y. Acad. Sci., 1088, 153 (2006); T.Henriques-Coelho et al., Endocrinology, 149, 4367 (2008); P.C.Reggiani et al., Ann. N. Y. Acad. Sci., 1153, 98 (2009); H.Folch et al., Biol. Res., 43, 291 (2010); M.Santos et al., Expert Opin. T
Cayman Chemical TC-FPR 43, Purity: ≥98%, CAS: 903895-98-7, 25 mg
An agonist of FPR1 and FPR2; induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner; inhibits fMLP- or IL-8-induced neutrophil migration (IC50s = 0.64 and 0.24 µM, respectively); reduces PGE2- and LTB4-induced ear swelling in mice at 50 mg/kg
CPC Scientific Benzoyl-Phe-Val-Arg-AMC (trifluoroacetate salt) 1MG
ONE-LETTER SEQUENCE: Benzoyl-FVR-AMCMOLECULAR FORMULA: C37H43N7O6MOLECULAR WEIGHT: 681.79STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [88899-22-3]SYNONYMS: Bz-Phe-Val-Arg-AMCRESEARCH AREA: HematologyREFERENCES:L. Svendsen, et al., Folia Haematol, 98, 446 (1972)R. Lottenberg, et al., Meth. Enz., 80, 341 (1981)
Biotium MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1)(2F6), CF594 conjugate, 0.1mg/mL
Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NFB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.
CPC Scientific Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH (trifluoroacetate salt) 5MG
For exerting its anti-inflammatory and immunomodulatory activity, the peptide hormone thymulin, pEAKSQGGSN, requires the presence of Zn(II). Thymulin showed promising results in experimental models of lung diseases as well as potential as an analgesic peptide.ONE-LETTER SEQUENCE: Pyr-AKSQGGSNMOLECULAR FORMULA: C33H54N12O15MOLECULAR WEIGHT:858.86STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [63958-90-7], RESEARCH AREA: ImmunomodulationREFERENCES: J.F.Bach et al., Bull. Inst. Pasteur, 325 (1978); T.L.K.Low and A.L.Goldstein, Springer Semin. Immunopathol., 2, 169 (1979); J.J.E.Haddad et al., Biochem. Biophys. Res. Commun., 274, 500 (2000); S.C.Land and F.Darakshan, Am. J. Physiol. Lung Cell. Mol. Physiol., 286, L473 (2004); M.Dardenne et al., Ann. N. Y. Acad. Sci., 1088, 153 (2006); T.Henriques-Coelho et al., Endocrinology, 149, 4367 (2008); P.C.Reggiani et al., Ann. N. Y. Acad. Sci., 1153, 98 (2009); H.Folch et al., Biol. Res., 43, 291 (2010); M.Santos et al., Expert Opin. T
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Human & Mouse Phospho-RNA polymerase II (Ser2) Detection Kit, 50,000 Assay Points
AlphaLISA SureFire Ultra Human & Mouse Phospho-RNA polymerase II (Ser2) Detection Kit, 50,000 Assay Points
Cayman Chemical ClusterIn MoncLNalCLN 9 100uL
An inhibitor of cardiac myosin ATPase (IC50 1.26 UM for the bovine enzyme) reduces fractional shortening in isolated rat cardiac ventricular myocytes (IC50 7.9 UM) as well as in rats in a dose-dependent manner
ILEX LIFE SCIENCES LLC BOVINE THROMBIN PROTEIN 2000 U
Ilex Life Sciences Thrombin Bovine, Purified Protein (2000 U). DESCRIPTION: Thrombin Bovine, purified native enzyme, lyophilized. CAS REGISTRY NO.: 9002-04-4. BIOLOGICAL ACTIVITY: 164 US units/mg protein (may vary with each lot number, please refer to enclosed datasheet). FORMULATION: Sterile filtered beige lyophilized powder; formulated with glycine, CaCl2 and sodium chloride, PH 6.8. APPLICATION: As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity. SYNONYMS: Activated Factor IIa, Factor 2A, F2, PT, RPRGL2, THPH1, coagulation factor II, EC 3.4.21.5, UniProtKB# P00735.
Cayman Chemical ClusterIn MoncLNalCLN 9 200uL
An inhibitor of cardiac myosin ATPase (IC50 1.26 UM for the bovine enzyme) reduces fractional shortening in isolated rat cardiac ventricular myocytes (IC50 7.9 UM) as well as in rats in a dose-dependent manner
Cayman Chemical Pseudoginsenoside F11, Purity: ≥98%, CAS: 69884-00-0, 50 mg
A ginsenoside with diverse biological activities; prevents tubular cell apoptosis, decreases in renal GPX and SOD levels, and increases in renal lipid peroxide levels in a rat model of cisplatin-induced nephrotoxicity at 10 mg/kg; reduces infarct size, brain water content, and cortical accumulation of autophagosomes in a rat model of ischemic stroke induced by permanent middle cerebral artery occlusion; inhibits morphine-induced memory impairment in the Morris water maze and development of morphine-induced conditioned place preference in mice at 4 and 8 mg/kg; reduces hippocampal AGE and MDA levels, increases hippocampal SOD activity and GSH levels, and attenuates cognitive impairment in the Morris water maze in a mouse model of D-galactose-induced mild cognitive impairment